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The research documentation of MusiCure
More than 20 years of development and the study of results from research with this original music, is the foundation for the creation of MusiCure, and today the music is used in a variety of different types of treatment and research projects in many countries.
In recent years, MusiCure Nature films has also been used as stimulus in scientific studies with children after day surgery at Odense University Hospital, and other patients during recovery after operations, with very positive results.

See MusiCure Documentary

Internationally published research articles

Since 2003, independent researchers and professional therapists from several countries have completed medical studies with MusiCure.
The results of these studies and controlled trials are currently published in several international medical journals, including: Heart & Lung - The Journal of Acute and Critical Care, European Journal of Cardiovascular Nursing, Intensive and Critical Care Nursing, Pediatric Anesthesia m. fl.

The published research results with the MusiCure music shows:

1 Significant reduction and lowering of stress,  anxiety and pain

2 Reduction of medication (PN medicine, Morfine, etc.)

3 Lowering the cortisol level (stress hormone)

4 Increase in oxytocin level ("peace/love hormone")

5 In general - Increased sense of calmness, well-being, motivation and inspiration

Research in the effect of music has been carried out with control groups and includes both quantitative and qualitative studies, subjective questionnaire and interview surveys, as well as purely physiological measurements on the patients.


Internationally published research articles with MusiCure

1. Music interventions in patients during coronary angiographic procedures: A randomized controlled study of the effect on patients’ anxiety and well-being. by Birgit P. Weeks, Northwest Hospital & Medical Center, Seattle, Washington, USA, and Ulrica Nilsson, Department of Anaesthesia and Intensive Care and Centre for Health Care Sciences, Örebro University Hospital, Sweden. Published in European Journal of Cardiovascular Nursing (2010)
2. School-aged children’s experiences of postoperative music medicine on pain, distress, and anxiety. Authors: Stefan Nilsson RN, MSC Department of Paediatric Anaesthesia and Intensive Care Unit, The Queen Silvia Children’s Hospital, Sweden, co-authors: Eva Kokinsky MD, PhD, Ulrica Nilsson RNA, PhD and Karin Enskär RN, PhD. Published in Paediatric Anaesthesia (2010)
3. Soothing music can increase oxytocin levels during bed rest after open-heart surgery: a randomised control trial. Author: Ulrica Nilsson Assisting Professor, RNA and PhD at the Centre for Health Care Sciences at Örebro University Sweden. Published in Journal of Clinical Nursing (2009)
4. Patients’ perception of music versus ordinary sound in a post anaesthesia care unit: a randomised crossover trial. Malmoe University Hospital, Sweden, Authors: Ann-Charlotte Fredriksson, Leif Hellström, Ulrica Nilsson. Published in Intensive and Critical Care Nursing (2009)
5. The effect of music intervention in stress response to cardiac surgery in a randomized clinical trial. Author: Ulrica Nilsson Professor, RNA and PhD at the Centre for Health Care Sciences at Örebro University Sweden. Published in Heart & Lung – The journal of Acute and Critical Care (2008)
6. Designed sound and music environment in post anaesthesia care units–a multicentre study of patients and staff. Authors: Thorgaard P, Ertmann E, Hansen V, Noerregaard A, Hansen V, Spanggaard L. Published in Intensive and Critical Care Nursing 2004
7. The effect of music on heart rate and motion artefacts during gamma camera acquisition for myocardial perfusion scintigraphy. (Internationally presented Poster from Herlev University Hoapital) By: Pulawska T., Gerhardt M., Sondergaard, S. and Zerahn,B.
8. Meaning, Power and Exoticism in Medicinal Music: A Case Study of MusiCure in Denmark. Author: Tore Tvarnø Lind – Tore Tvarnø Lind is Assistant Professor in ethnomusicology at the Department of Arts and Cultural Studies, University of Copenhagen.2.November 2007. Published in Ethnomusicology Forum 2007.
9. Specially selected music in the cardiac laboratory—an important tool for improvement of the wellbeing of patients. Authors: Gøtzsche B, Henriksen BB, Pedersbaek G, Thomsen I. Published in European journal of Cardiovascular Nursing (2003)
10. Implicit Processing of Visual Emotions Is Affected by Sound-Induced Affective States and Individual Affective Traits. by Tiziana Quarto, Giuseppe Blasi, Karen Johanne Pallesen, Alessandro Bertolino and Elvira Brattico – Published at PLOS ON (2014)
11. Effectiveness of music interventions for women with high anxiety during coronary angiographic procedures - a randomized controlled study. Author: Ulrica Nilsson, Professor, PhD & RNA, Örebro University, Sweden. Published in European Journal of Cardiovascular Nursing 2012
12. Randomized Controlled Trial on the Impact of Music Therapy During Cardiac Catheterization on Reactive Hyperemia Index and Patient Satisfaction: The Functional Change in Endothelium After Cardiac Catheterization, With and Without Music Therapy (FEAT) Study. Author(s): Lindsay Ripley, BS; Georgios Christopoulos, MD; Tesfaldet T. Michael, MD; Mohammed Alomar, MD; Bavana V. Rangan, BDS, MPH; Michele Roesle, RN; Anna Kotsia, MD, PhD; Subhash Banerjee, MD; Emmanouil S. Brilakis, MD, PhD. Published in Journal of Invasive Cardiology (2014)
13. The effect of music intervention in relation to gender during coronary angiographic procedures: a randomized clinical trial. Authors: Nilsson U, Lindell L, Eriksson A, Kellerth T. Department of Cardiothoracic Surgery, Orebro University Hospital, Sweden. Published in European Journal of Cardiovascular Nursing (2009)

Review articles:

14. Music as an aid for postoperative recovery in adults: a systematic review and meta-analysis – a review article, by Jenny Hole, Martin Hirsch, Elizabeth Ball and Catherine Meads. Published August 13. 2015 in The Lancet (with reference to 5 studies using MusiCure by Niels Eje).
15. The Effects of Perioperative Music Interventions in Pediatric Surgery – by Marianne J. E. van der Heijden, Sadaf Oliai Araghi, Monique van Dijk, Johannes Jeekel and M. G. Myriam Hunink. Published August at PLOS ONE (2015) (with reference to the study: School-aged children’s experiences of postoperative music medicine on pain, distress, and anxiety, by Stefan Nilsson et al.)

Articles published in Nordic Journals and by Musica Humana Research, and Bachelor projects:

1. Treatment with MusiCure of psychiatric patients suffering from anxiety – a pilot study. Author and project coordinator: Torben Egelund Soerensen, Candidate in Music therapy, Psychiatric Department, Horsens Hospital, Denmark. Supervisor: Joergen Tybjerg, MD, Consultant Psychiatrist, Psychiatric Department, Horsens Hospital, Denmark. Published in Psykiatrien – Årsskrift 4 (2005)

2. Designed sound environment for heart patients before and after invasive procedures. Author and study leader: Bitten Gøtzsche, Ward Nurse, Cardiac Laboratory, Department of Cardiology, Aalborg University Hospital, Denmark. Published 2010
3. Can music improve patients’ mental wellbeing perioperatively? By Marianne Jungersen, Surgical Nurse, Day surgery Department R, Ullevaal University Hospital, Norway Published in the Norwegian nurse sheet “Overview” 2006, and at Musica Humana Research
4. Music intervention among children with autism spectrum disorder and sleeping difficulties. By Susan Gulstad, Education Consultant, Egebakken – school for children with autism, Denmark and Dr. Per Thorgaard, Aalborg University Hospital. Published 2006
5. Music for patients in intensive care and recovery wards at Odense University Hospital Music therapy during the recovery process after major surgical procedures. By Vibeke Hansen, Specialist nurse at VITA, Odense University Hospital and Anni Nørregaard, Clinical nurse teacher, ICU V, Odense University Hospital. Published by Musica Humana 2004
6. Summary of project Ataraxia. By PhD student, music therapist, teacher Karin Schou. A project at Aalborg University Hospital, Aalborg, Denmark, describing the effect of music on pain, nausea, well being and anxiety in a post anaesthetic care unit. Number of patients: 200 - Published November 2003 by Musica Humana
7. Music reduces anxiety and discomfort during dialysis treatment. By Hanne Agnholt, clinical nurse, and nurses Birthe Gross, Inger Bjerre Rosa, Fantahun Wassie Ketema, and Birgitte Schantz Laursen, senior researcher. Published in journal ‘Dialäsen’ (2011)
8. Reduction of anxiety in heart patients using existential psychology & music medicine 
A Bachelor student project at the Danish Nursing school, by Morten Thomas Guldager. Published 2010
9. Musikkens muligheder (music options) – a bachelor project about the use of music for children with cancer, by Rose Marie Majlund Kent, Department of Arts and Cultural Studies at Copenhagen University. Published 2013
10. Musikpuden (The music pillow) – en kvalitativ undersøgelse af depressive patienters oplevelse af velvære (a bachelor project about treatment with MusiCure music and MusiCure Pillow to patients suffering from depression). by Paula M. Ihlen, Amalie Vincensen, Zenia Hansen og Camilla E. Hess – University College Sjælland – Campus Næstved 2016
11. Neurosurgicel Intensive Care patients and the effect of music therapy (Neurokirurgisk intensive patienters effekt af terapeutisk brug af musik). Et bachelorprojekt fra 2007 af Søren Ebdrup, (in Danish).
12. Our Musical Brain. By Lars Heslet, Professor, Dr. Med. Head of Intensive Care Section 4131, Danish State Hospital, Published by Musica Humana November 2003
13. Medicine and Music - The use of specially designed music in Intensive Care Section 4131, Danish State Hospital Copenhagen Denmark By Lars Heslet Professor, Dr. Med. Head of ICU 4131, Rigshospitalet, Copenhagen Published by Musica Humana June 2003
MusiCure in Healthcare®
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